Pluripotent embryonic stem cells (ESCs) can be obtained from early embryos, and induced pluripotent stem cells (iPSCs) can be generated from ordinary somatic cells through a reprogramming process. These cells are pivotal in which they are able to give rise to nearly all the body cell types, thus providing renewable sources for generating desired cell types for cell therapy as well as valuable tools for modeling human diseases and cellular differentiation.
Our research focus on the underlying molecular mechanism governs the stem cell maintenance and differentiation of these stem cells. Research interests include the discovery of new reprogramming factors, novel regulators for the maintenance and reinstatement of stem cell identity, as well as developing new technologies and molecular tools to promote stem cell research and their applications in disease therapy.
We believe comprehending stem cell regulatory network using advanced molecular and informatics approaches will facilitate us to explore the use of ESCs and iPSCs, as well as their derivatives for therapeutic purposes.