Low-dose AAV-CRISPR-mediated liver-specific knock-in restored hemostasis in neonatal hemophilia B mice with subtle antibody response                                                                     

He X*, Zhang Z*, Xue J, Wang Y, Zhang S, Wei J, Zhang C, Wang J, Urip BA, Ngan CC, Sun J, Li Y, Lu Z, Zhao H, Pei D, Li CK, Feng B.                                                                             

Nat Commun 13, 7275 (2022)

Kidney tubular transcription co-activator, Yes-associated protein 1 (YAP), controls the expression of collecting duct aquaporins and water homeostasis                         

Zhang Y, Huang H, Kong Y, Xu C, Dai L, Geng X, Deng Y, Wang Y, Liu Y, Meng C, Zhang X, Li J, Qin J, Feng B, Mak KK, Wang L, Huang Y, Wang W, Lan HY, Yang B, Lu HAJ, Xia Y.                     

Kidney Int 22, S0085-2538 (2022)

R4 RGS proteins suppress engraftment of human hematopoietic stem/progenitor cells by modulating SDF-1/CXCR4 signaling                                                                         

Chan KYY, Zhang C, Wong YTS, Zhang XB, Wang CC, Ng WH, Fok SP, Tang PMK, Kang W, Feng B, Poon ENY, Lee KY, Lee CK, Chen C, Leung TY, Ng MHL, To KF, Wang H, Lam HS, Ng PC, Yuen PMP, Li K, Leung AWK, Li CK, Leung KT.                                                                           

Blood Adv 5, 4380-4392 (2021)

Review: Evolving AAV-delivered therapeutics towards ultimate cures   

He X, Urip BA, Zhang Z, Ngan CC, Feng B.   

J Mol Med (Berl) 99, 593-617 (2021)

Establishment of a novel CYP3A4-transduced human hepatic sinusoidal endothelial cell model and its application in screening hepatotoxicity of pyrrolizidine alkaloids  

Lu Y, Wong KY, Tan C, Ma J#, Feng B#, Lin G#.     

J Environ Sci Health C Toxicol Carcinog 38, 169-185 (2020)

Review: The rapidly advancing Class 2 CRISPR-Cas technologies: A customizable toolbox for molecular manipulations       

Wang J, Zhang C, Feng B.  

J Cell Mol Med 24, 3256-3270 (2020)

Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming  

Xiong L, Wu F, Wu Q, Xu L, Cheung OK, Kang W, Mok MT, Szeto LLM, Lun CY, Lung RW, Zhang J, Yu KH, Lee SD, Huang G, Wang CM, Liu J, Yu Z, Yu DY, Chou JL, Huang WH, Feng B, Cheung YS, Lai PB, Tan P, Wong N, Chan MW, Huang TH, Yip KY, Cheng AS, To KF.    

Nat Commun 10, 335 (2019)

Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells

Zhang C*, He X*, Kwok YK, Wang F, Xue J, Zhao H, Suen KW, Wang CC, Ren J, Chen GG, Lai PBS, Li J, Xia Y, Chan AM, Chan WY#, Feng B#. 

BMC Biology 16, 151 (2018)

Review: New turns for high efficiency knock-in of large DNA in human pluripotent stem cells

He X, Li YX, Feng B.

Stem Cells Int 3, 9465028 (2018)

Review: In vivo genome editing thrives with diversified CRISPR technologies

Ma X, Wong ASY, Tam HY, Tsui SYK, Chung DLS, Feng B.

Zool Res 39, 58-71 (2018)

Conversion of human gastric epithelial cells to multipotent endodermal progenitors using defined small molecules

Wang Y, Qin J, Wang S, Zhang W, Duan J, Zhang J, Wang X, Yan F, Chang M, Liu X, Feng B, Liu J,  Pei X.

Cell Stem Cell 19, 449-461 (2016)

Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair 

He X, Tan C, Wang F, Wang Y, Zhou R, Cui D, You W, Zhao H, Ren J, Feng B.

Nucleic Acids Res 44, e85 (2016)

Review: Genome-wide massive sequencing in embryonic stem cell biology: Recent insights and challenges 

Wang Y, Cheung AC, Guo JT, Feng B.     

J Stem Cell Res Ther 5, 296 (2015)

Review: Progress and challenges in generating functional hematopoietic stem/progenitor cells from human pluripotent stem cells      

Liu S, Xu Y, Zhou Z, Feng B#, Huang H#.        

Cytotherapy 17, 344-58 (2015)

Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors   

Hu J, Lei Y, Wong WK, Liu S, Lee KC, He X, You W, Zhou R, Guo JT, Chen X, Peng X, Sun H, Huang H, Zhao H, Feng B.       

Nucleic Acids Res 42, 4375-90 (2014)

Zfp322a regulates mouse ES cell pluripotency and enhances reprogramming efficiency 

Ma H, Ng HM, Teh X, Li H, Lee YH, Chong YM, Loh YH, Collins JJ, Feng B, Yang H#, Wu Q#.

PLoS Genet 10, e1004038 (2014)

LIF-dependent primitive neural stem cells derived from mouse ES cells represent a reversible stage of neural commitment

Tsang WH*, Wang B*, Wong WK*, Shi S*, Chen X, He X, Gu S, Hu J, Wang C, Liu PC, Lu G, Chen X, Zhao H, Poon WS, Chan WY#, Feng B#.

Stem Cell Res 11, 1091-102 (2013)

SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells

Lu X*, Goke J*, Sachs F, Jacques PE, Liang H, Feng B, Bourque G, Bubulya PA, Ng HH.

Nat Cell Biol 15, 1141-1152 (2013)

A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo

Do DV, Ueda J, Messerschmidt DM, Lorthongpanich C, Zhou Y, Feng B, Guo G, Lin PJ, Hossain MZ, Zhang W, Moh A, Wu Q, Robson P, Ng HH, Poellinger L, Knowles BB, Solter D#, Fu XY#.

Genes Dev 27, 1378-90 (2013)

Efficient commitment to functional CD34+ progenitor cells from human bone marrow mesenchymal stem-cell-derived induced pluripotent stem cells

Xu Y, Liu L, Zhang L, Fu S, Hu Y, Wang Y, Fu H, Wu K, Xiao H, Liu S, Yu X, Zheng W, Feng B, Huang H.

PLoS One 7, e34321 (2012)

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

Chia NY*, Chan YS*, Feng B*, Lu X, Orlov YL, Moreau D, Kumar P, Yang L, Jiang J, Lau MS, Huss M, Soh BS, Kraus P, Li P, Lufkin T, Lim B, Clarke ND, Bard F#, Ng HH#.

Nature 468, 316-20 (2010)

The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells   

Heng JCD, Feng B, Han J, Jiang J, Kraus P, Ng JH, Orlov YL, Huss M, Yang L, Lufkin T, Lim B, Ng HH.       

Cell Stem Cell 6, 167-74 (2010)

Review: Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells     

Feng B, Ng JH, Heng JCD, Ng HH#.

Cell Stem Cell 4, 301-12 (2009)

Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb     

Feng B, Jiang J, Kraus P, Ng JH, Heng JCD, Chan YS, Yaw LP, Zhang W, Loh YH, Han J, Vega VB, Cacheux-Rataboul V, Lim B, Lufkin T, Ng HH.          

 Nat Cell Biol 11, 197-203 (2009) 

* Co-first authors     

# Co-Correspondence author


© 2023, Prof. Feng Bo, The Chinese University of Hong Kong.